Restrata :: Acera Surgical Inc.

Micronized, electrospun fiber matrix engineered to be similar to human ECM. A dispersible form factor of Restrata that may be applied to soft tissue areas with irregular or complex topography.

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Restrata MiniMatrix

A micronized, dispersible form of Restrata, MiniMatrix may be applied to soft tissue areas with irregular or complex topography.⁷ Individual pieces of the micronized matrix are less than 3.15 mm in diameter.⁶

Product Benefits

Free of human or animal tissue components, resulting in no special storage or handling requirements.⁵
Dispersible form factor that may be applied dry or hydrated.
Resistant to enzymatic degradation, staying in the defect long enough to support soft tissue formation due to a controlled resorption rate via hydrolysis.^{1, 3, 4}

Representative image of multiple particles of Restrata MiniMatrix

Representative image of a single particle of Restrata MiniMatrix

Intended for use in the management of wounds, including:⁷

Partial- and full-thickness wounds
Draining wounds
Pressure sores/ulcers, venous ulcers, diabetic ulcers, chronic vascular ulcers, tunneled/undermined wounds
Surgical wounds (e.g., donor site/grafts, post-laser surgery, post-Mohs surgery, podiatric wounds, and dehisced wounds)
Trauma wounds (e.g., abrasions, lacerations, partial-thickness burns, and skin tears)

About Electrospun Fiber Matrix Technology

Fiber size, structure and porosity similar to human extracellular matrix that supports: Granulation tissue formation, cellular ingrowth and retention, vascularization through structural cues, instead of growth factors.^{1, 3, 4}
Shown to elicit a mildly acidic environment for tissue healing.⁸
Supported by Level I clinical evidence.¹⁰

MiniMatrix fibers sold in sealed tubular packages from 100mg to 2000mg

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1. MacEwan MR, MacEwan S, Wright AP, Kovacs TR, Batts J, Zhang L. Comparison of a Fully Synthetic Electrospun Matrix to a Bi-Layered Xenograft in Healing Full Thickness Cutaneous Wounds in a Porcine Model. Cureus. 2017;9(8):e1614. Published 2017 Aug 27. doi:10.7799/cureus.1614.
2. EDS-70003-03
3. MacEwan MR, MacEwan S, Kovacs TR, Batts J. What Makes the Optimal Wound Healing Material? A Review of Current Science and Introduction of a Synthetic Nanofabricated Wound Care Scaffold. Cureus. 2017;9(10):e1736. Published 2017 Oct 2. doi:10.7799/cureus.1736
4. Regulski MJ, MacEwan MR. Implantable Nanomedical Scaffold Facilitates Healing of Chronic Lower Extremity Wounds. Wounds. 2018;30(8): E77-E80.
5. MKG-20002-15
6. EDS-71006-12
7. MKG-20007-03
8. SMKG-10064-02
9. Data on File
10. Husain K, Malik A, Kirchens J, Choi G. A Prospective, Blinded, Randomized Controlled Clinical Trial Evaluating the Effect of the Synthetic Electropsun Fiber Matrix in the Treatment of Chronic Diabetic Foot Ulcers. Foot & Ankle Surgery: Techniques, Reports & Cases. Published online January 1, 2024:100362-100362. doi:https://doi. org/10.1016/j.fastrc.2024.100362