Clinical Compendium

A summary of peer-reviewed publications with Restrata.

The body of published clinical data on Restrata continues to grow.

Since 2018, Acera Surgical products have been the subject of 34 peer-reviewed publications and counting that reinforce the healing power of Restrata. See the chart below for information on each publication.

A New Standard in Clinical Results

Average Closure Rate

Average Weeks to Closure^a

Average Number of Applications

Acute Wounds

Surgical

96%

3.8^c

1.4

Chronic Wounds

DFUs

82%

8.3

5.4^b

VLUs

89%

10.2

5.9^b

Limb Salvage

86%

14.7

1.8

Acute Wounds

Surgical

Average Closure Rate

96%

Average Weeks to Closure^a

3.8^c

Average Number of Applications

1.4

Chronic Wounds

DFUs

Average Closure Rate

82%

Average Weeks to Closure^a

8.3

Average Number of Applications

5.4^b

VLUs

Average Closure Rate

89%

Average Weeks to Closure^a

10.2

Average Number of Applications

5.9^b

Limb Salvage

Average Closure Rate

86%

Average Weeks to Closure^a

14.7

Average Number of Applications

1.8

a) Chronic wounds to closure, surgical wounds to re-granulation or skin graft application

Acute Wounds Include: Necrotizing soft-tissue infection (NSTI) resections, skin cancer resections, traumatic wounds, calciphylaxis, sarcoma resections, post-Mohs wounds, hematomas, and flap donor sites

c) Analyzed in studies in which granulation was reported

Chronic Wounds Include: Diabetic foot ulcers (DFUs), venous leg ulcers (VLUs), transmetatarsal amputations (TMAs), partial ray amputations, Lisfranc amputations, pressure ulcers (PUs), neuropathic ulcers, dehisced surgical wounds, and non-healing traumatic wounds

b) Two studies did not report average number of applications for DFU patients. One study did not report average number of applications for VLU patients.

Summary of Select Publications
Select a disease state below for the list of publications

Acute Wounds

Chronic Wounds

Critical Care

Plastic Surgery

Oncology

Head & Neck

Orthopedic Trauma

Soft Tissue Reinforcement

Pre-Clinical and Mechanism of Action

DFUs

VLUs

Limb Salvage

Other Chronic Wounds

Title ^{Click to view full publications}	Author(s)	Journal	Restrata-Treated Wounds	Summary of Outcomes	Level of Evidence
Title ^{Click to view full publications} Utility of synthetic electrospun fiber matrix in general surgery: From head to toe²⁷	Author(s) Hagen SS	Journal Surgery	Restrata-Treated Wounds 22	Summary of Outcomes 89.5% reach clinical goals	Level of Evidence III
Title ^{Click to view full publications} Synthetic Electrospun Fiber Matrix in the Management of Acute Wounds Following Excision of Hidradenitis Suppurativa Lesions: A Prospective Pilot Study³³	Author(s) Madueke M, et al.	Journal Polymers	Restrata-Treated Wounds 21	Summary of Outcomes Successfully promoted granulation tissue for STSG application	Level of Evidence III
Title ^{Click to view full publications} Synthetic hybrid-scale fiber matrix in the trauma and acute care surgical practice¹⁶	Author(s) Fernandez LG, et al.	Journal Wounds	Restrata-Treated Wounds 3	Summary of Outcomes Significant reepithelialization and wound healing	Level of Evidence V
Title ^{Click to view full publications} Treatment of Hematomas Using a Synthetic Hybrid-Scale Fiber Matrix¹⁸	Author(s) Temple EW.	Journal Cureus	Restrata-Treated Wounds 2	Summary of Outcomes 100% complete closure	Level of Evidence V
Title ^{Click to view full publications} Synergistic Clinical Application of Synthetic Electrospun Fiber Wound Matrix in the Management of a Complex Traumatic Wound: Degloving Left Groin and Thigh Auger Injury¹⁵	Author(s) Fernandez LG, et al.	Journal Wounds	Restrata-Treated Wounds 1	Summary of Outcomes Successfully promoted granulation tissue for STSG application	Level of Evidence V
Title ^{Click to view full publications} Treatment of traumatic crush injury using a synthetic hybrid-scale fiber matrix in conjunction with split-thickness skin graft¹⁷	Author(s) Martini CJ, et al.	Journal Foot & Ankle Surgery: Techniques, Reports & Cases	Restrata-Treated Wounds 1	Summary of Outcomes Stimulated granulation tissue for STSG application	Level of Evidence V
Title ^{Click to view full publications} Management of irradiated post-mastectomy wound dehiscence with synthetic electrospun fiber matrix: A case report¹²	Author(s) Montminy T, Oppenheimer N, Cocco D.	Journal Frontiers in Oncology	Restrata-Treated Wounds 1	Summary of Outcomes 100% complete wound closure	Level of Evidence V
Title ^{Click to view full publications} A Synthetic Hybrid-scale Fiber Matrix for Complex Surgical Wounds: Consensus Guidelines¹⁹	Author(s) Fernandez LG, et al.	Journal Wounds	Restrata-Treated Wounds N/A (consensus guidelines)	Summary of Outcomes Overview of clinical use scenarios and recommendations	Level of Evidence V

Title ^{Click to view full publications}	Author(s)	Journal	Restrata-Treated Wounds	Summary of Outcomes	Level of Evidence
Title ^{Click to view full publications} Utility of a Synthetic Hybrid-Scale Fiber Matrix in Surgical Soft Tissue Reconstruction²⁰	Author(s) Chowdhry S.	Journal ePlasty	Restrata-Treated Wounds 22	Summary of Outcomes 100% wound closure. Demonstrated efficacy encouraging granulation tissue for healing by secondary intent, STSG or flap.	Level of Evidence III
Title ^{Click to view full publications} Reconstruction of Post-Mohs Surgical Wounds Using a Novel Nanofiber Matrix²³	Author(s) McGowan J.	Journal Wounds	Restrata-Treated Wounds 4	Summary of Outcomes 100% complete closure	Level of Evidence III
Title ^{Click to view full publications} Utility of synthetic hybrid-scale fiber matrix in dermatologic wounds²⁴	Author(s) Zaiac M, et al.	Journal JAAD Case Reports	Restrata-Treated Wounds 2	Summary of Outcomes 100% complete wound closure	Level of Evidence V
Title ^{Click to view full publications} Novel Use of a Synthetic Electrospun Wound Matrix in an Extensive Forearm Degloving Injury: Case Report and Review of the Literature³²	Author(s) Tacconi, K, et al.	Journal Plastic and Reconstructive Surgery Global Open	Restrata-Treated Wounds 1	Summary of Outcomes Significant reepithelialization and wound healing	Level of Evidence V

Title ^{Click to view full publications}	Author(s)	Journal	Restrata-Treated Wounds	Summary of Outcomes	Level of Evidence
Title ^{Click to view full publications} Wound Healing Outcomes Following Treatment With Synthetic Hybrid-Scale Fiber Matrix After Resection of Soft Tissue Tumors or Infections²¹	Author(s) Lindeque B, Moon D.	Journal Wounds	Restrata-Treated Wounds 10	Summary of Outcomes 70% wound closure. Improving graft incorporation via supporting healthy granulation tissue formation or closed via secondary intent. 30% lost to follow-up.	Level of Evidence III
Title ^{Click to view full publications} Management of irradiated post-mastectomy wound dehiscence with synthetic electrospun fiber matrix: A case report¹²	Author(s) Montminy T, Oppenheimer N, Cocco D.	Journal Frontiers in Oncology	Restrata-Treated Wounds 1	Summary of Outcomes 100% complete wound closure	Level of Evidence V

Title ^{Click to view full publications}	Author(s)	Journal	Restrata-Treated Wounds	Summary of Outcomes	Level of Evidence
Title ^{Click to view full publications} Applications of Synthetic Hybrid-Scale Fiber Matrix in Head and Neck Reconstruction: A Case Series²²	Author(s) Horwich P, et al.	Journal Case Reports in Oncology	Restrata-Treated Wounds 13	Summary of Outcomes 100% wound closure	Level of Evidence III

Title ^{Click to view full publications}	Author(s)	Journal	Restrata-Treated Wounds	Summary of Outcomes	Level of Evidence
Title ^{Click to view full publications} Soft Tissue Reconstruction With Synthetic Electrospun Fiber Matrix Following Musculoskeletal Injury: A Retrospective Case Series³⁴	Author(s) Cosgrove C.	Journal ePlasty	Restrata-Treated Wounds 11	Summary of Outcomes 10 patients achieved successful soft tissue closure without complication.	Level of Evidence III

Title ^{Click to view full publications}	Author(s)	Journal	Restrata-Treated Wounds	Summary of Outcomes	Level of Evidence
Title ^{Click to view full publications} Lower extremity wounds treated with a synthetic hybrid-scale fiber matrix⁵	Author(s) Barton EC, Abicht BP.	Journal Foot & Ankle Surgery: Techniques, Reports & Cases	Restrata-Treated Wounds 23	Summary of Outcomes 96% complete wound closure	Level of Evidence III
Title ^{Click to view full publications} Assessment of a Novel Augmented Closure Technique for Surgical Wounds Associated with Transmetatarsal Amputation: A Preliminary Study²⁹	Author(s) Alexander J, et al.	Journal JAPMA	Restrata-Treated Wounds 10	Summary of Outcomes Versus standard of care control patients, Restrata-augmented TMAs demonstrated 20% higher rate of complete healing, 18% reduction in time to healing, 29% reduction in incidence of dehiscence, 39% reduction in additional procedures, and 20% reduction in limb loss	Level of Evidence III
Title ^{Click to view full publications} Lower Extremity Orthopedic Augmentation Utilizing a Synthetic Hybrid-Scale Fiber Matrix³⁰	Author(s) Rushing CJ.	Journal Cureus	Restrata-Treated Wounds 10	Summary of Outcomes All patients achieved complete healing in an average of 12 days post-operatively	Level of Evidence III

Title ^{Click to view full publications}	Author(s)	Journal	Restrata-Treated Wounds	Summary of Outcomes	Level of Evidence
Title ^{Click to view full publications} What Makes the Optimal Wound Healing Material? A Review of Current Science and Introduction of a Synthetic Nanofabricated Wound Care Scaffold²⁵	Author(s) MacEwan, M, et al.	Journal Cureus	Restrata-Treated Wounds N/A (mechanism of action)	Summary of Outcomes N/A (mechanism of action)	Level of Evidence N/A (mechanism of action)
Title ^{Click to view full publications} Comparison of a Fully Synthetic Electrospun Matrix to a Bi-Layered Xenograft in Healing Full Thickness Cutaneous Wounds in a Porcine Model²⁶	Author(s) MacEwan, M, et al.	Journal Cureus	Restrata-Treated Wounds 6 (6 xenograft treated wounds)	Summary of Outcomes Increased collagen maturation, granulation tissue, and epithelialization at day 15 in the Restrata group	Level of Evidence N/A
Title ^{Click to view full publications} Antimicrobial Effectiveness Testing of Resorbable Electrospun Fiber Matrix per United States Pharmacopeia (USP) <51>³¹	Author(s) Sallade E, et al.	Journal Cureus	Restrata-Treated Wounds N/A	Summary of Outcomes In-vitro, Restrata demonstrated passing results against various bacterial and fungal strains per United States Pharmacoepia <51> standards for Antimicrobial Effectiveness	Level of Evidence N/A

Title ^{Click to view full publications}	Author(s)	Journal	Restrata-Treated Wounds	Summary of Outcomes	Level of Evidence
Title ^{Click to view full publications} A prospective, blinded, randomized controlled clinical trial evaluating the effect of the synthetic electrospun fiber matrix in the treatment of chronic diabetic foot ulcers¹	Author(s) Husain K, et al.	Journal Foot & Ankle Surgery: Techniques, Reports & Cases	Restrata-Treated Wounds 19	Summary of Outcomes 74% complete wound closure in Restrata per -protocol group; 33% complete wound closure in the control per-protocol group	Level of Evidence I
Title ^{Click to view full publications} Evaluation of wound healing of diabetic foot ulcers in a prospective clinical trial using a synthetic hybrid-scale fiber matrix²	Author(s) Abicht BP, et al.	Journal Foot & Ankle Surgery: Techniques, Reports & Cases	Restrata-Treated Wounds 24	Summary of Outcomes 75% complete wound closure	Level of Evidence II
Title ^{Click to view full publications} Implantable nanomedical scaffold facilitates healing of chronic lower extremity wounds³	Author(s) Regulski MJ, MacEwan MR.	Journal Wounds	Restrata-Treated Wounds 82	Summary of Outcomes 85% complete wound closure	Level of Evidence III
Title ^{Click to view full publications} Treatment of complex lower extremity wounds utilizing synthetic hybrid-scale fiber matrix⁴	Author(s) Husain K, et al.	Journal JAPMA	Restrata-Treated Wounds 23	Summary of Outcomes 96% complete wound closure	Level of Evidence III
Title ^{Click to view full publications} Lower extremity wounds treated with a synthetic hybrid-scale fiber matrix⁵	Author(s) Barton EC, Abicht BP.	Journal Foot & Ankle Surgery: Techniques, Reports & Cases	Restrata-Treated Wounds 23	Summary of Outcomes 96% complete wound closure	Level of Evidence III
Title ^{Click to view full publications} Utility of synthetic electrospun fiber matrix in general surgery: From head to toe²⁷	Author(s) Hagen SS	Journal Surgery	Restrata-Treated Wounds 22	Summary of Outcomes 89.5% reach clinical goals	Level of Evidence III
Title ^{Click to view full publications} Utility of synthetic hybrid-scale fiber matrix in complex lower extremity wounds: A case series⁶	Author(s) Benson B.	Journal Foot & Ankle Surgery: Techniques, Reports & Cases	Restrata-Treated Wounds 10	Summary of Outcomes 100% complete wound closure	Level of Evidence III
Title ^{Click to view full publications} Impact of a novel synthetic nanofibre matrix to treat hard-to-heal wounds⁷	Author(s) Herron K.	Journal Journal of Wound Care	Restrata-Treated Wounds 5	Summary of Outcomes Complete closure, decrease in wound area, stimulation of granulation tissue	Level of Evidence III
Title ^{Click to view full publications} The Use of a Synthetic Hybrid-Scale Fiber Matrix to Treat Difficult-to-Heal Wounds⁸	Author(s) Wilson M.	Journal Cureus	Restrata-Treated Wounds 6	Summary of Outcomes 67% complete wound closure	Level of Evidence III

Title ^{Click to view full publications}	Author(s)	Journal	Restrata-Treated Wounds	Summary of Outcomes	Level of Evidence
Title ^{Click to view full publications} Implantable nanomedical scaffold facilitates healing of chronic lower extremity wounds³	Author(s) Regulski MJ, MacEwan MR.	Journal Wounds	Restrata-Treated Wounds 82	Summary of Outcomes 85% wound closure	Level of Evidence III
Title ^{Click to view full publications} Synthetic Hybrid-Scale Fiber Matrix for the Treatment of Complex Lower-Extremity Wounds⁴	Author(s) Husain K, et al.	Journal JAPMA	Restrata-Treated Wounds 23	Summary of Outcomes 96% wound closure	Level of Evidence III
Title ^{Click to view full publications} Lower extremity wounds treated with a synthetic hybrid-scale fiber matrix⁵	Author(s) Barton EC, Abicht BP.	Journal Foot & Ankle Surgery: Techniques, Reports & Cases	Restrata-Treated Wounds 23	Summary of Outcomes 96% wound closure	Level of Evidence III
Title ^{Click to view full publications} Utility of synthetic electrospun fiber matrix in general surgery: From head to toe²⁷	Author(s) Hagen SS	Journal Surgery	Restrata-Treated Wounds 22	Summary of Outcomes 89.5% reach clinical goals	Level of Evidence III
Title ^{Click to view full publications} Impact of a novel synthetic nanofibre matrix to treat hard-to-heal wounds⁵	Author(s) Herron K.	Journal Journal of Wound Care	Restrata-Treated Wounds 5	Summary of Outcomes Complete closure, decrease in wound area, stimulation of granulation tissue	Level of Evidence III
Title ^{Click to view full publications} The Use of a Synthetic Hybrid-Scale Fiber Matrix to Treat Difficult-to-Heal Wounds⁸	Author(s) Wilson M.	Journal Cureus	Restrata-Treated Wounds 6	Summary of Outcomes 67% complete wound closure	Level of Evidence III

Title ^{Click to view full publications}	Author(s)	Journal	Restrata-Treated Wounds	Summary of Outcomes	Level of Evidence
Title ^{Click to view full publications} Utility of synthetic hybrid-scale fiber matrix in complex lower extremity wounds: A case series⁶	Author(s) Benson B.	Journal Foot & Ankle Surgery: Techniques, Reports & Cases	Restrata-Treated Wounds 10	Summary of Outcomes 100% complete wound closure	Level of Evidence III
Title ^{Click to view full publications} Clinical Evaluation of a Synthetic Hybrid-Scale Matrix in the Treatment of Lower Extremity Surgical Wounds⁹	Author(s) Tucker D.	Journal Cureus	Restrata-Treated Wounds 9	Summary of Outcomes 78% complete closure	Level of Evidence III
Title ^{Click to view full publications} The Use of a Synthetic Hybrid-Scale Fiber Matrix to Treat Difficult-to-Heal Wounds⁸	Author(s) Wilson M.	Journal Cureus	Restrata-Treated Wounds 6	Summary of Outcomes 67% complete wound closure	Level of Evidence III
Title ^{Click to view full publications} Treatment of traumatic crush injury using a synthetic hybrid-scale fiber matrix in conjunction with split-thickness skin graft¹⁷	Author(s) Martini CJ, et al.	Journal Foot & Ankle Surgery: Techniques, Reports & Cases	Restrata-Treated Wounds 1	Summary of Outcomes Stimulated granulation tissue for STSG application	Level of Evidence V
Title ^{Click to view full publications} Application of abductor digiti minimi muscle flap and synthetic electrospun fiber matrix after resection of osteomyelitis of fifth meatarsal: A two-patient case report²⁸	Author(s) Patel S	Journal Foot & Ankle Surgery: Techniques, Reports & Cases	Restrata-Treated Wounds 2	Summary of Outcomes 100% wound closure	Level of Evidence V

Title ^{Click to view full publications}	Author(s)	Journal	Restrata-Treated Wounds	Summary of Outcomes	Level of Evidence
Title ^{Click to view full publications} Utility of synthetic electrospun fiber matrix in general surgery: From head to toe²⁷	Author(s) Hagen SS	Journal Surgery	Restrata-Treated Wounds 22	Summary of Outcomes 89.5% reach clinical goals	Level of Evidence III
Title ^{Click to view full publications} Implantable Nanomedical Scaffold Facilitates Healing of Chronic Lower Extremity Wounds³	Author(s) Regulski MJ, MacEwan MR.	Journal Wounds	Restrata-Treated Wounds 82	Summary of Outcomes 85% wound closure	Level of Evidence III
Title ^{Click to view full publications} Lower extremity wounds treated with a synthetic hybrid-scale fiber matrix⁵	Author(s) Barton EC, Abicht BP.	Journal Foot & Ankle Surgery: Techniques, Reports & Cases	Restrata-Treated Wounds 23	Summary of Outcomes 96% wound closure	Level of Evidence III
Title ^{Click to view full publications} Utility of synthetic hybrid-scale fiber matrix in complex lower extremity wounds: A case series⁶	Author(s) Benson B.	Journal Foot & Ankle Surgery: Techniques, Reports & Cases	Restrata-Treated Wounds 10	Summary of Outcomes 100% complete wound closure	Level of Evidence III
Title ^{Click to view full publications} Impact of a novel synthetic nanofibre matrix to treat hard-to-heal wounds⁷	Author(s) Herron K.	Journal Journal of Wound Care	Restrata-Treated Wounds 5	Summary of Outcomes Complete closure, decrease in wound area, stimulation of granulation tissue	Level of Evidence III
Title ^{Click to view full publications} Fully Synthetic Bioengineered Nanomedical Scaffold in Chronic Neuropathic Foot Ulcers¹⁰	Author(s) Killeen AL, et al.	Journal Wounds	Restrata-Treated Wounds 4	Summary of Outcomes Stimulated granulation tissue while preventing necrosis	Level of Evidence III
Title ^{Click to view full publications} Use of a synthetic hybrid-scale fiber matrix in the management of chronic and complex wounds: A retrospective case series¹¹	Author(s) Price T.	Journal Wounds	Restrata-Treated Wounds 28	Summary of Outcomes 89% complete wound closure	Level of Evidence III
Title ^{Click to view full publications} The Use of a Synthetic Hybrid-Scale Fiber Matrix to Treat Difficult-to-Heal Wounds⁸	Author(s) Wilson M.	Journal Cureus	Restrata-Treated Wounds 6	Summary of Outcomes 67% complete wound closure	Level of Evidence III
Title ^{Click to view full publications} Management of irradiated post-mastectomy wound dehiscence with synthetic electrospun fiber matrix: A case report¹²	Author(s) Montminy T, Oppenheimer N, Cocco D.	Journal Frontiers in Oncology	Restrata-Treated Wounds 1	Summary of Outcomes 100% complete wound closure	Level of Evidence V
Title ^{Click to view full publications} Histopathologic Analysis of a Recalcitrant Calcaneal Wound Treated Using a Synthetic Hybrid-scale Fiber Matrix¹³	Author(s) Harder JG, MacKay, BJ, et al.	Journal Plastic and Reconstructive Surgery Global Open	Restrata-Treated Wounds 1	Summary of Outcomes Successful granulation tissue formation, histological assessment	Level of Evidence V
Title ^{Click to view full publications} Treatment of a Complex Pressure Ulcer Using a Synthetic Hybrid-Scale Fiber Matrix¹⁴	Author(s) Herron K.	Journal Cureus	Restrata-Treated Wounds 1	Summary of Outcomes Significant healing	Level of Evidence V

References

Husain K, Malik A, Kirchens J, Choi G. A Prospective, Blinded, Randomized Controlled Clinical Trial Evaluating the Effect of the Synthetic Electropsun Fiber Matrix in the Treatment of Chronic Diabetic Foot Ulcers. Foot & Ankle Surgery: Techniques, Reports & Cases. Published online January 1, 2024:100362-100362. doi:https://doi.org/10.1016/j.fastrc.2024.100362‌
Abicht BP, Deitrick GA, MacEwan MR, Jeng L. Evaluation of wound healing of diabetic foot ulcers in a prospective clinical trial using a synthetic hybrid-scale fiber matrix. Foot & Ankle Surgery: Techniques, Reports & Cases. 2022;2(1):100135. doi:10.1016/j.fastrc.2021.100135
Regulski MJ, MacEwan MR. Implantable Nanomedical Scaffold Facilitates Healing of Chronic Lower Extremity Wounds. Wounds. 2018;30(8):E77-E80.
Husain K, Malik A, Kirchens J. Synthetic Hybrid-Scale Fiber Matrix for the Treatment of Complex Lower-Extremity Wounds. J Am Podiatr Med Assoc. 2023;113(1):21-071. doi:10.7547/21-071
Barton EC, Abicht BP. Lower extremity wounds treated with a synthetic hybrid-scale fiber matrix. Foot & Ankle Surgery: Techniques, Reports & Cases. 2021;1(3):100076. doi:10.1016/j.fastrc.2021.100076
Benson B. Utility of synthetic hybrid-scale fiber matrix in complex lower extremity wounds: A case series. Foot &amp; Ankle Surgery: Techniques, Reports &amp; Cases. 2023;3(3): 100317. doi:10.1016/j.fastrc.2023.100317
Herron K. Impact of a novel synthetic nanofibre matrix to treat hard-to-heal wounds. Journal of Wound Care. 2022;31(11):962-968. doi:10.12968/jowc.2022.31.11.962
Wilson M. The Use of a Synthetic Hybrid-Scale Fiber Matrix to Treat Difficult-to-Heal Wounds. Cureus. 2023;15(12):e50405. Published 2023 Dec 12. doi:10.7759/cureus.50405
Tucker D. Clinical evaluation of a synthetic hybrid-scale matrix in the treatment of lower extremity surgical wounds. Cureus. July 2022. doi:10.7759/cureus.27452
Killeen AL, Brock KM, Loya R, Honculada CS, Houston P, Walters JL. Fully Synthetic Bioengineered Nanomedical Scaffold in Chronic Neuropathic Foot Ulcers. Wounds. 2018;30(10).
Price T. Use of a synthetic hybrid-scale fiber matrix in the management of chronic and complex wounds: a retrospective case series. Wounds. 2023;35(6):E197-E202. doi:10.25270/wnds/22091
Montminy T, Oppenheimer NE, Cocco D. Management of irradiated post-mastectomy wound dehiscence with synthetic electrospun fiber matrix: a case report. Front Oncol. 2024;14:1371122. Published 2024 Apr 18. doi:10.3389/fonc.2024.1371122
Harder JG, Hernandez EJ, MacEwan MM, et al. Histopathologic Analysis of a Recalcitrant Calcaneal Wound Treated Using a Synthetic Hybrid-scale Fiber Matrix. Plast Reconstr Surg Glob Open. 2024;12(2):e5597. Published 2024 Feb 6. doi:10.1097/GOX.0000000000005597
Herron K. Treatment of a Complex Pressure Ulcer Using a Synthetic Hybrid-Scale Fiber Matrix. Cureus. 2021;13(4):e14515. Published 2021 Apr 16. doi:10.7759/cureus.14515
Fernandez LG, Orsi C, Okeoke B, et al. Synergistic clinical application of synthetic electrospun fiber wound matrix in the management of a complex traumatic wound: degloving left groin and thigh auger injury. Wounds. 2024;36(4):124-128. doi:10.25270/wnds/23117
Fernandez L, Shar A, Matthews M, et al. Synthetic hybrid-scale fiber matrix in the trauma and acute care surgical practice. Wounds. 2021;33(9):237–244. doi:10.25270/wnds/2021.237244
Martini CJ, Burgess B, Ghodasra JH. Treatment of traumatic crush injury using a synthetic hybrid-scale fiber matrix in conjunction with split-thickness skin graft. Foot & Ankle Surgery: Techniques, Reports & Cases. 2022;2(1):100112. doi:10.1016/j.fastrc.2021.100112
Temple EW. Treatment of hematomas using a synthetic hybrid-scale fiber matrix. Cureus. 2022. doi:10.7759/cureus.26491
Fernandez LG, Matthews MR, Kim PJ. A synthetic hybrid-scale fiber matrix for complex surgical wounds: consensus guidelines. Wounds. 2023;35(5):E160-E168. doi:10.25270/wnds/22067
Chowdhry S. Utility of a Synthetic Hybrid-Scale Fiber Matrix in Surgical Soft Tissue Reconstruction. Eplasty. 2024;24:e2. Published 2024 Jan 4.
Lindeque B, Moon D. Wound healing outcomes following treatment with synthetic hybrid-scale fiber matrix after resection of soft tissue tumors or infections. Wounds. 2024;36(2):34-38. doi:10.25270/wnds/23091
Horwich P, Sivarajah S, Neskey D, Hornig J. Applications of synthetic hybrid-scale fiber matrix in head and neck reconstruction: A case series. Case Reports in Oncology. 2024;17(1):622-629. doi:10.1159/000539200
McGowan J. Reconstruction of post-Mohs surgical wounds using a novel nanofiber matrix. Wounds. Published online July 18, 2022. doi:10.25270/wnds/20150
Zaiac M, Kauffman M, Matin T, Rosen J, Sallade E. Utility of synthetic hybrid-scale fiber matrix in dermatologic wounds. JAAD Case Rep. 2023;40:109-111. Published 2023 Aug 29. doi:10.1016/j.jdcr.2023.08.020
MacEwan MR, MacEwan S, Kovacs TR, Batts J. What Makes the Optimal Wound Healing Material? A Review of Current Science and Introduction of a Synthetic Nanofabricated Wound Care Scaffold. Cureus. 2017;9(10):e1736. Published 2017 Oct 2. doi:10.7759/cureus.1736
MacEwan MR, MacEwan S, Wright AP, Kovacs TR, Batts J, Zhang L. Comparison of a Fully Synthetic Electrospun Matrix to a Bi-Layered Xenograft in Healing Full Thickness Cutaneous Wounds in a Porcine Model. Cureus. 2017;9(8):e1614. Published 2017 Aug 27. doi:10.7759/cureus.1614
Hagen SS. Utility of synthetic electrospun fiber matrix in general surgery: From head to toe. Surgery. 2024;176(4):1233-1238. doi:10.1016/j.surg.2024.06.052
Patel S. Application of abductor digiti minimi muscle flap and synthetic electrospun fiber matrix after resection of osteomyelitis of fifth metatarsal: A two-patient case report. Foot & Ankle Surgery: Techniques, Reports & Cases. Published online August 2024:100418. doi:10.1016/j.fastrc.2024.100418
Alexander J, Desai V, Sharif Denden, Alianello N. Assessment of a Novel Augmented Closure Technique for Surgical Wounds Associated with Transmetatarsal Amputation: A Preliminary Study. Journal of the American Podiatric Medical Association. 2022;112(5). doi:https://doi.org/10.7547/20-256
Rushing CJ. Lower Extremity Orthopedic Augmentation Utilizing a Synthetic Hybrid-Scale Fiber Matrix. Cureus. 2023;15(9):e45046. Published 2023 Sep 11. doi:10.7759/cureus.45046
Sallade E, Grimes D, Jeng L, et al. Antimicrobial Effectiveness Testing of Resorbable Electrospun Fiber Matrix per United States Pharmacopeia (USP) . Cureus. 2023;15(12). doi:https://doi.org/10.7759/cureus.50055‌
Tacconi KA, Deering AJ, Malekpour M, Wang HT. Novel use of a synthetic electrospun wound matrix in an extensive forearm degloving injury: Case report and review of the literature. Plastic and Reconstructive Surgery - Global Open. 2025;13(9). doi:10.1097/gox.0000000000007094
Madueke M, Lau F. Synthetic Electrospun Fiber Matrix in the Management of Acute Wounds Following Excision of Hidradenitis Suppurativa Lesions: A Prospective Pilot Study. Polymers. 2025; 17(19):2563. https://doi.org/10.3390/polym17192563
Cosgrove C. Soft Tissue Reconstruction With Synthetic Electrospun Fiber Matrix Following Musculoskeletal Injury: A Retrospective Case Series. ePlasty. 2025;25:e37.

Disclaimer: Restrata has not been studied in wounds that extend into the tendon, muscle, joint capsule, or bone. Please refer to the Product's Instructions for Use for a full list of indications, contraindications, precautions, and warnings.

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Clinical Compendium

The body of published clinical data on Restrata continues to grow.

A New Standard in Clinical Results

Summary of Select PublicationsSelect a disease state below for the list of publications

Contact us to learn more

Summary of Select Publications
Select a disease state below for the list of publications