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Mechanism of Action

Electrospun nanofibers are a revolution in soft-tissue repair.  

The unique properties of electrospun nanofibers have been shown to produce exceptional healing results, even in refractory wounds. Fibers range from 500nm to 1500nm and are designed for similarity in size and organization to the human extracellular matrix (ECM). The resulting matrix functions as a scaffold for tissue regeneration. Cellular migration is encouraged by the range of nanofiber sizes and their deliberately engineered organization. Once in the wound bed, cells proliferate rapidly. Throughout the healing process, the nanofibers promote continued cellular migration, while also working to maintain cellular retention and enable soft-tissue regeneration, neovascularization, and epithelialization. 

The demonstrated advantages of engineered, synthetic nanofibers over foreign human and animal grafts have practical benefits for clinicians and patients. For some patients with ethical or religious concerns, nanofibers present an option for healing consistent with personal preferences or faith. Additionally, because the nanofibers are fully resorbable, there is no material left at the application site, reducing the risk of chronic inflammation1, which can slow or limit healing in wounds treated with traditional biologics. During application, electrospun nanofiber products are capable of conforming to wound surfaces while also withstanding clinician handling and even suturing, if needed.

As healing progresses, the rate of resorption is controlled through an engineered resistance to enzymatic degradation2, designed to match tissue ingrowth. The persistent scaffold supports healing over a longer course of time with fewer applications required. Although the nanofibers do not contain active agents or drugs, the component material has been shown to have antimicrobial properties, which may protect the wound bed and support the healing process.3

The demonstrated capability of engineered nanofibers to support healing in refractory wounds has introduced a new era in soft-tissue repair. 1

1,2,3 What Makes the Optimal Wound Healing Material? A Review of Current Science and Introduction of a Synthetic Nanofabricated Wound Care Scaffold

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Cerafix®, Covora®, and Restrata® are registered trademarks of Acera Surgical Inc.
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